How to Get the Dose Right with Psilocybin Truffles
One of the most important factors leading to a beneficial magic truffle session is finding a dosage that is well calibrated to your intention. I would argue that it is of equal importance to the set and setting when it comes to a positive outcome.
As magic truffles are kinda new in the psychedelic world compared to classic magic mushrooms, the doses are not well understood.
Below, I’ll share my calculations to match the doses of synthetic psilocybin used in 4 major and influential studies to the corresponding dose of magic truffles. Synthetic psilocybin is easy to measure and dose compared to raw mushrooms, and is therefore used exclusively in clinical trials. Below, I share my calculations.
Doses Used In Clinical Research
1. Psilocybin-occasioned mystical-type experience
Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors – Roland R. Griffiths, Matthew W. Johnson, William A. Richards, Brian D. Richards, Robert Jesse, Katherine A. MacLean, Frederick S. Barrett, Mary P. Cosimano, and Maggie A. Klinedinst (2018)
Participants tripped twice, with a month between each session, with:
(1) high dose of 20 mg
(2) high dose of 30 mg
Doses calculated per 70kg bodyweight.
2. Psilocybin with psychological support for treatment-resistant depression
Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study – Robin L. Carhart-Harris, Mark Bolstridge, James Rucker, Camilla M.J. Day, David Erritzoe, Mendel Kaelen, Michael Bloomfield, James A Rickard, Ben Forbes, Amanda Feilding, David Taylor, Steve Pilling, Valerie H. Curran, David J. Nutt (2016)
Participants tripped twice, with a week between each session:
(1) low dose of 10 mg
(2) high dose of 25 mg
Doses regardless of bodyweight.
3. Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial – Roland R. Griffiths, Matthew W. Johnson, Michael A. Carducci, Annie Umbricht, William A. Richards, Brian D. Richards, Mary P. Cosimano and Margaret A. Klinedinst (2016)
Participants tripped twice, with 5 weeks between each session:
(1) high dose of 22 or 30 mg
(2) very low (placebo-like) dose of 1 or 3 mg
Doses calculated per 70kg bodyweight.
4. Psilocybin in the Treatment of Tobacco Addiction
Pilot Study of the 5-HT2AR Agonist Psilocybin in the Treatment of Tobacco Addiction – Matthew W. Johnson, Albert Garcia-Romeu, Mary P. Cosimano, and Roland R. Griffiths (2014)
On a 15 week course participants tripped 2-3 times:
(1) moderate dose of 20mg at week 5
(2) moderate or high dose of 20 or 30 mg at week 7
(3) optional session with either 20 or 30 mg at week 13
Doses calculated per 70kg bodyweight.
Converting to Fresh Truffle Weight
One 15 g pack of truffles
The exact psilocybin content of truffles is, as far as I can find, unknown, but going off of the calculation that 1 g of fresh truffles will contain between 0.75 and 1.75 mg of psilocybin (link), we have a reasonable window with which to find a comparable dosage of fresh truffles. Keep in mind that potency may vary by strain and that individual tolerance varies depending on both physiological and psychological factors (more on this another time).
The information below is presented as a rough guide and calculated with fresh truffle weight. (If your truffles are dried, the equivalent dose will be significantly less. Fully dried truffles are approximately ⅓ the weight of fresh truffles. So for example, if the fresh truffle dose was 13g, you could calculate 13 / 3 = to get a dried truffle dose of 4.33 g.)
The best way to find the dosage right for you is through personal experience. Start low, document your sessions, and gradually work your way up.
If you are considering to go DIY and organise your own session at home or without a sitter, remember that the psilocybin sessions in the research studies mentioned are accompanied by psychological support before, during, and after each session.
Pure (Synthetic) Psilocybin Doses Converted to Truffle Weight
10 mg psilocybin – Low dose
10 / 0.75 = 13.33
10 / 1.25 = 8
10 / 1.75 = 5.71
6 – 13 g fresh truffles
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20 mg psilocybin – Moderate dose
20 / 0.75 = 26.66
20 / 1.25 = 16
20 / 1.75 = 11.43
11 – 27 g fresh truffles
–
25 mg psilocybin – High dose
25 / 0.75 = 33.33
25 / 1.25 = 20
25 / 1.75 = 14.29
14 – 33 g fresh truffles
–
30 mg psilocybin – High dose
30 / 0.75 = 40
30 / 1.25 = 24
30 / 1.75 = 17.14
17 – 40 g fresh truffles
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Final Thoughts
Generally speaking, I’d recommend lower doses for recreational trips, creative thinking, and active problem solving, and scaling up to higher doses for therapeutic experiences, deep inner journeys, and peak mystical experiences.
Safe journeys!
