mdma psilocybin combine combo how to guide
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Combining MDMA and Psilocybin: A Guide to Enhance Your Journey

If you’ve been finding it difficult to relax and open up in your psilocybin journeys, then you might consider combining it with MDMA.

MDMA can help bring about a more relaxed, open-hearted space, which is an ideal state, or set, to enter a psilocybin journey.

There are a few members inside our The Conscious Psychedelic Explorer community who have tried this combination and it has been giving pretty good results, so I thought I’d write about it as part of MDMA month on the blog.

In this blog post, I’ll cover the potential benefits of this combination and offer suggestions on dosages and timings, as well as share some experience from members of the community and myself.

mdma psilocybin combine combo how to guide

Benefits of Combining MDMA and Psilocybin

I first heard about this combination given serious credence in the book Psychedelic Psychotherapy by Coleman. An excellent read, which I highly recommend btw.

Coleman mentions that leading with a dose of MDMA before a psilocybin journey can help ‘soften the entrance’. The general positive atmosphere and reduced fear response that MDMA provides can set the perfect stage for entering a psilocybin experience, where darker material may arise from deep in our psyches. This allows us to be more open to such experiences.

As such, this combination can be helpful for working through traumatic material or engaging in shadow work.

Safety Considerations

Combining MDMA and psilocybin is generally well-tolerated and if you’re not contraindicated for either, the combo is as safe as taking each substance individually. If you’re clear to take both and in general good health, the main thing is to be psychologically prepared as these can be intense and challenging experiences.

It’s advisable to try and sample batches of each substance before embarking on a significant journey. Potency can vary between batches. As always, remember to prepare your setting carefully and cautiously.

As usual, follow standard best practices for MDMA.

Dosages and Recommendations

Prevailing advice online suggests starting with lower doses of each substance because of the synergistic effect of combining.

However, I’d say it depends on your level of experience and your intentions for the session.

For experienced psychonauts going for a psychedelic therapy style session, for example, I think closer to a standard dose of both can be considered. For example, if your standard for MDMA is 120 mg, then 110 mg. Because if you’re taking MDMA, you want it to work its magic.

If you’re new to psychedelics but have experience with MDMA, I would suggest starting with a standard dose of MDMA and a conservative dose of psilocybin, equivalent to the level of experience you’re after (mini/low/medium/high dose), with an option for a psilocybin booster.

If you’ve tried psilocybin but not MDMA, I’d suggest starting with a conservative dose of MDMA, and considering a booster. Then, when you reach a point with the MDMA where you feel ready to dive into more psychedelic waters, then dose the psilocybin.

One final consideration is that whilst you might fast before a psilocybin journey, you might not want to do this before a session with MDMA as it could potentially result in stomach cramping.

Timing Options

There are a few different ways you might time your dosing. Here are a couple you might consider.

1. MDMA ~70 minutes before Psilocybin

The standard recommendation for timing I would offer is the one Coleman offers in Psychedelic Psychotherapy.

This means dosing the MDMA approximately 70 minutes before the psilocybin. This is so that the journeyer can utilise the effects of the MDMA to have a softer entry into the psilocybin experience.

An alternative to this is to dose MDMA first and then, once you are feeling the effects, dose psilocybin. This ensures that you are in the MDMA space for the entirety of the come-up and entry into the psilocybin space.

One thing to note is that the effects of MDMA last a shorter time than psilocybin. (3-5 hours compared to the 4-6 of psilocybin). So this combined with the fact you’re dosing MDMA earlier will mean that the MDMA will wear off before the psilocybin, and the later part of your psilocybin will be without the MDMA.

I think this is fine as typically the most challenging part of the psilocybin experience is the coming up, and the first one to two hours. Typically the most challenging or pressing material to be negotiated will arise here so that’s where the MDMA’s effects will be most appreciated.

However, if you would prefer the MDMA for the whole psilocybin experience, you can take a booster dose of MDMA to extend it. The standard is half the initial dose ~90 minutes after. You might like to pre-weigh that booster dose, have it ready, and set a timer just to make it easier to navigate during the middle of your trip.

However, if you would like them to last the same generation at the same time you can dose the take a booster dose of MDMA at some point. You might like to send you the 

2. MDMA ~20 minutes before psilocybin

Another option, recently suggested by a colleague, is to take MDMA first and then psilocybin about 20 minutes later.

Due to the differences in onset time, both substances’ effects will hit you at once, with both peaks hitting at the same time. 

The come-up will be more intense and I wouldn’t recommend this to novices. However, one upside I have heard from this approach is that there’s less opportunity for you to be stuck in your head. The journey just gets underway and takes you in.

So if you find that you have a tendency to be a bit stuck in your head or find it difficult to when you’re waiting for the effects of substances to kick in, this might be suitable for you. It might also be useful if you find it difficult to let go and fully immerse yourself in the experience. This way is equivalent to jumping into the deep end of the experience. I’d recommend considering a sitter for this option.

Other Timing Options

The other options are then taking both at the same time, or taking the psilocybin first, and then the MDMA later. 

Taking Both Simultaneously

Taking both at the same time means that the psilocybin will likely start slightly before the MDMA, which I don’t really see any point in. One upside, however, is that it’s easy and straightforward. You just take everything and then wait. No synchronizing timings, no clocks needed. As one of my friends calls this no-nonsense approach: ‘JBI’ – ‘Just Bosh It’.

Psilocybin Before MDMA

The final option of course is taking the psilocybin first and then taking the MDMA later. I don’t really have any experience of this myself or from people that I know so I’m not gonna comment on it or recommend it here. 

Experiences from the Community

This approach has been experimented with by a few members of The Conscious Psychedelic Explorer community, as I mentioned before. They have reported that taking MDMA before embarking on the psilocybin experience helps them feel more clear and connected to the heart center.

Here are a few comments:

“I feel the combination really helped me surrender to my experience. I encountered some really hard and traumatic past experiences in my journey and I think the MDMA opened and softened my heart allowing me to resolve these things from a place of forgiveness and not judgment or guilt or shame. […] I noticed my heart rate pick up with the MDMA, and just reminded myself to relax and focus on my breathing.”

“I have tried that combination with good results. MDMA is a gentle way into the shrooms (less turbulence perhaps) and then, you don’t get the rough comedown from MDMA because you are still high on the psilocybin”

“I definitely came in a state of focus, calm and readiness. As for me both substances kicked in together (peak) it was overwhelming but mystical.”

My Experience

This combination is not one I have experimented with much personally. I have found it pleasant on the couple of occasions that I have done it, and they were helpful. I followed the Coleman timing on dosing, which I found to work well and ease the entry as planned.

However, I have had more experience combining MDMA with LSD. Probably the first five or six times I took LSD, they were all combined with MDMA. In my research and preparation for those experiences, I read online that taking MDMA first can be a good idea as it helps to get you into a positive mindset and a positive state, which is a good place to enter the psychedelic journey from. So, in that respect, a lot of the same principles apply. And I have to say, it worked very well. I remember being with friends and getting into a good space with the MDMA first. Then, there would come a point where I felt ready for the LSD, feeling good and prepared, and then we would dive in.

Because of the success of the initial session, that approach actually became my modus operandi for my first year of psychedelic explorations. Those experiences were formative, mind-expanding, and treasured moments. It wasn’t until about a year into my psychedelic explorations that I actually journeyed with LSD alone.

However, I believe those early experiences helped me build a solid relationship with psychedelics, providing positive first encounters and setting the stage well for future experiences. Of course, it was always combined with a good set and setting—I was in safe, private spaces with close friends.

Final Thoughts

I hope this post is helpful, informative, or useful in some way. If you’re considering hippie flipping, then as usual, take good care, factor in your setting, and follow a solid preparation. Feel free to reach out if you have any questions.

Best of luck out there.

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How To Avoid Nausea When Taking Psilocybin

A reader recently reached out to me and asked about dealing with nausea from psilocybin.

This is a common issue with shrooms so, in an effort to find out more, I put it out there to the psychedelic Twitter community.

twitter shrooms

With the help of a retweet from The Daily Shroom I received a wide variety of answers. In this blog post I summarise them for other users…

Tea

Making a brew seems to be a good option. Here’s a quick step-by-step:

  1. Crush or grind your dose of mushrooms or truffles put them in a mug or other container.
  2. Bring water to boil.
  3. Pour hot water over your dose. You can add some fresh herbs, ginger or another type of tea for flavour. Ginger can help to lessen any nausea.
  4. Give it a good stir and let it infuse for for 10 minutes. Periodically stir it to get those juices flowing.
  5. Add honey or a sweetener if you’d like to sweeten it.
  6. Drink your tea! To be sure you get 100% of your dose, either do another round of hot water or eat up the mushies or truffles left in the bottom of your mug. If nausea if your concern, strain out the pieces and only consume the liquid.

Lemon Tek

This method breaks down the psilocybin to psilocin before entering the digestive system and apparently there’s some research which shows this helps with nausea.

To lemon tek:

  1. Crush or grind your mushrooms well and put in a glass or bowl. The more crushed up, the better.
  2. Cover your dose with freshly squeezed lemon juice, enough to cover them, so they’re bathing in it.
  3. Let sit for 20-25 minutes (not longer), stirring every 5 minutes.
  4. Drink the whole mix. You might like to mix it with a tea beforehand, to improve the taste.

It has been claimed that the ‘lemon tek’ method will make your trip come on faster and harder. I can’t neither confirm nor deny this claim, but I will say that the lemon flavour helps to mask the taste of the shrooms.

Lemon Essential Oil

On the citrus note, one of the members of The Conscious Psychedelic Explorer course has found luck with lemon oil:

“Out of everything I’ve tried so far, lemon essential oil (in a gel capsule) seems to work best for me at preventing nausea. Should also work with any other serotonergic substance, as it contains Beta-Pinene, which is a 5-HT3 antagonist.”

Take on an empty stomach

This is a technique that I personally use, though admittedly I do still sometimes have some nausea. It was a widespread answer on the Twitter thread so there must be something to it. It makes sense that if your body is not having to digest food then you’re not gonna have those stomach grumblings to be sensitive to during your trip.

Take with food

Interestingly many people advised taking food with the shrooms, or eating food shortly after.

This could be to mask the taste of the shrooms or to somehow settle the stomach in another way. Chocolate was a common recommendation, as was honey. A few people shared eating something fatty helps, like coconut oil, peanut butter or greasy chips, and a couple of people said they swear by this method.

Clean up your diet

This is something which can be done on the long term and also on the short term. On the short term this can mean eating very clean the day before or the week leading up to your trip. You might like to check out my post: food suggestions for before, during, and after psychedelic sessions

I do suspect, though I have no strong evidence for it, that cleaning up your diet generally and improving that aspect of your physical health will lead to a decrease in the experience of nausea from psilocybin. Consider what eating a clean diet means to you. Thinking about how to improve that aspect of your physical health might be a little ongoing side project for you that will aid your psychedelic journeys.

Ginger!

This was the most common reply and was something we also used on the New Moon Psychedelic Retreats. It seems that fresh ginger is the best and most effective. Chewing on raw ginger can also help to mask the taste and having something soft like that to bite on can be good when dealing with strong waves of nausea.  Other options include tea, high-quality extract, and capsules.

Peppermint

I have never tried this but it makes sense as peppermint is known to relax the digestive system. Most people recommended a peppermint tea but it was also suggested to use essential oil:

“Rub some peppermint essential oils on your hands and inhale and exhale slowly, […] breathe in the smell.”
– @DitchTheEgo

Marijuana

This one was competing with ginger for the most common reply. This is one I have used to excellent effect with San Pedro, where there can be very strong nausea. However, I have never used it with psilocybin. The Twitter thread shows that this is a widespread and effective method for many people. One thing I’d mention is that you want to consider how the effect of marijuana is going to affect your trip. The psychoactive effect is a reason why I personally don’t use weed with psilocybin. Someone did mention CBD, so that might be a way of utilising the soothing effect of the marijuana plant without the psychoactive effect.

Grind and encapsulate

Drying and grinding is something I do. To me it just makes sense that having part of the breaking up of the matter itself already done makes it easier for the body to handle. More than one person mentioned the efficacy of encapsulating powder.

“Grind them into dust with a coffee grinder. Get gel cap stuffing tools and 000 gel caps. Filling a 000 cap as much as you can stuff it is within .05 of a half gram. I hate whole ones and have never had nausea issues this way”
– @tylerfarnworth

If eating, try chewing very well before swallowing. The saliva can already begin the process of digestion and as with any food, chewing well helps aid digestion.

Breathing and stillness

Lying down, remaining still, breathing, relaxing into and accepting your current experience is always a good way of dealing with any unpleasant feelings that just won’t go away, nausea or otherwise. Acceptance.

Consider a synthetic alternative

You might consider switching to a psilocybin pro drug like 4-AcO-DMT. A couple of users said they swear by this so it might be worth a shot.

“I recommend try switching to one of the psilocin prodrugs such as 4-AcO-DMT. I actually prefer using 4-AcO than shrooms since dosage and potency is much more consistent, and it doesn’t make me nauseous at all (none of the toxins contained in normal shrooms)”
– @flakyfarseer

Acclimate through microdosing

It was also suggested to allow the body to acclimate to psilocybin by microdosing in the run-up to the trip.

Tomato Paste

This is another one that came from one of the founding members of The Conscious Psychedelic Explorer. The theory here is chitin (a fibrous substance found in mushrooms) causes inflammation, which can cause issues in the lower bowel or gut, and this can result in discomfort. Tomato paste contains chitinase which counters these effects by dissolving or digesting the chitin. 

This journeyer noted that, whilst they used to experience discomfort…

“…I have not had any issues since I started adding the tomato paste.”

Here is their method, a mix of tea and paste:

“It is basically lemon tea plus tomato paste. I soak the ground up mushrooms in lemon juice (enough to wet the mixture – about a 1/4 lemon) and a dab of tomato paste (1/3 – 1/2 tsp). I let that sit for about ten minutes before steeping in hot water for another 10 – 15. I then make my tea adding honey and ginger to mask the awful taste….

Anti sickness medication

This is not one I would personally recommend. However, I will include it in the interest of brevity as it was mentioned by a few people. Names that were thrown up were Zofran and Dramamine.

Experiment, Document, Personalise

When it comes to taking psychedelics, I encourage all users to experiment and find their own personalised approach. There is no one-size-fits-all. We are all different and different approaches will suit different people.

I recommend keeping a drug journal or log and trying different methods and taking notes. In regards to nausea, you can note how you served your dose, what you ate and when you ate it relative to your dose, and how your experience of nausea was. Eventually, you will find what works for you and have your own personalised approach.

You can also find more in my articles on dose and nerdy drug taking.

Happy dosing!

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How to Dry, Store & Dose Magic Truffles

Legal in the Netherlands, psilocybin containing magic truffles are one of the only legal psychedelics anywhere in the world. The problem with them is that they can get rotten quite quickly, growing a nasty mould and becoming inedible and unusable. As such, it’s very useful to dry them when they are still fresh as this extends their shelf life for a long time, meaning they can be stored for many months. The good news is that the process of drying magic truffles is actually very easy and takes only a few days.

This post will cover how to dry truffles and then how to store them. With our dried truffles, I’ll finally show you how to calculate a desired dose, equivalent to their fresh weight doses.

How to Dry Magic Truffles

psilocybin magic truffles

Take your truffles out of whatever packaging they might be in and lay them out on a sheet of paper, leaving space between each of the pieces. The spaces allow air flow, which aids the drying process. The paper should be kinda absorbent (e.g. not fine printer paper), newspaper works fine.

Break up bigger truffles into smaller pieces as this will also help to speed up their drying process. As best you can, leave this in a place where there is a good air flow. For example, somewhere out in the open, or in the middle of a room is ideal.

If you aren’t able to leave them in an open place which is well ventilated, they will still dry but will just take longer. If this is the case, just fan them with some air from time to time to get the air around them flowing, making sure there isn’t any stagnant air around them.

Be sure to occasionally let fresh air into the room and to allow air to flow through. You can keep a fan over them but it’s not necessary.

psilocybin magic truffles dry

If you have them, put packets of silica gel by them which will help to absorb moisture in the air around them and can help to speed up the process.

Left like this, you can expect your truffles to dry completely in 2-3 days. In some cases, it might take up to a week. If you can, it is best to leave them out for a day or two longer to make sure they are completely dried.

You will know they are completely dried by the fact that they become extremely hard, to the point that it’s not possible to break them by hand. Half dried, they will be harder, but completely dried they become like stones.

Once they are dry, you can store them away.

How To Store Magic Truffles

Put your dried truffles into a container and keep them in a cool, dark place. Kept like this they will maintain a shelf life of many months.
dried magic truffles powder

Dried and powdered magic truffles

How to Take Dried Truffles

Because they are so incredibly hard, chewing dried truffles is not an option as it is with fresh ones. I’ve found easiest way to consume dried truffles is to grind them into a fine powder, mix with water, and then drink the whole mix. It doesn’t taste great, but it works.

A coffee grinder works well to grind the truffles. After grinding, wait a few minutes before opening the grinder to allow the truffle powder dust to settle.

Dosing with Dried Truffles

psilocybin magic truffles microdose scales

The process of drying truffles makes them lose a lot of their weight. It is important to take this change into account when calculating your dose with dried truffles. As a general rule of thumb, dried weight equates to one third of fresh weight, so 30 g fresh truffles becomes 10 g of dried truffles. However, it is best to weigh batches of truffles when they are fresh and then dried to know exactly the quantity that you have as the dried weight can vary depending on how thoroughly they have been dried – it can be that truffles are partially dried, becoming hard, but still carrying some water weight, meaning that they are closer to half of the weight of fresh truffles.

Weight your batch of fresh truffles and make a note of their weight.

After drying them, weigh them again to see the change in weight.

Then when it comes to calculating your dose, weigh the powder before (I recommend weighing the powder directly before preparing the dose rather than the dried truffles as parts of the truffles can get caught in the grinder).

An Equation To Calculate Desired Truffle Dose

Here is a useful equation you can use to calculate your dried truffle dose from your fresh truffle dose.

N/B*F = D

N = What truffles weigh now

B = What they weighed before

F = Desired dose fresh

D = Dose with current truffles

For example:

Say you had a batch that was 55 g of fresh truffles.
They have been dried, and now their total weight is 19.5 g
You want a dose of 25 g of fresh truffles.

So,

19,5/55*25 = 8.86 g

So your dose is 8.86 g of dried truffles.
psilocybin magic truffles

The material

Prepare well, set your space, and journey well!

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The Importance of Dose

A reader recently commented on a post that they tried microdosing but it didn’t work for them. My first question was, how much did they experiment with the dose?

Finding the right personalised dose can take a lot of trial and error. We are all different and effects can vary substantially between individuals. This is true not just with microdosing but also higher doses and I think that finding the correct dose is an oft underestimated key to using psychedelics.

Consider this:

A medicine can be a poison depending on the dose.

The exact same substance, the same chemical compound, one that could heal you, could also kill you, depending on the dose.

Suffice to say that dose can completely change a drug’s effects.

Though the psychedelics psilocybin and LSD are incredibly non-toxic, meaning that a fatal overdose is basically impossible, one could still consider an experience to be ‘poisonous’ in so much that it has negative effects on a persons psyche or wellbeing.

Dosage is, I venture to say, the number one reason why people have bad trips. Set and setting has been mentioned, say, people at festivals or parties around large groups of people, loud music, a lot of stimulation. But what about if they had taken a much lower dose? Would it have been overwhelming? Mightn’t they have gotten the enhanced party experience or mind opening adventure they were after?

I have had my own too-much experience at a festival, and whilst it was big flashing lights and lack of a quiet space to lie down that could seem to be the problem, I could have had a more pleasant experience by simply being careful with the amount I was taking. Not everyone wants to have a peak mystical experience or deep inner journey, sometimes people just want to enhance their experience of something else they already enjoy. Much in the way coffee would enhance a workday, a mini or museum dose might enhance a party, concert or brainstorming session.

Dosage is More Important than Set and Setting

As has been said by the late, great Boston psychonaut Kilindi Iyi, at very very high doses of magic mushrooms, set and setting doesn’t make any difference whatsoever. So that would mean that dosage is the most important factor in a session.

Though this is on the extreme end, I think it illustrates a good point. Dose is, in my opinion, too often and too easily overlooked when it comes to taking drugs.

Consider for a moment the difference between:

  • a shot of vodka vs. bottle of vodka
  • one tiny puff of weed vs. a huge bong rip
  • a bump of ketamine vs. a big line

Very different experiences.

So how to get it right?

Here’s some practical tips when it comes to exploring substances.

Practical Tips on Dosing

Use scales

Invest in a good set of scales and use them carefully. Especially important when using potent psychedelics that are active in very small doses like 2C-B, or those with higher toxicity like MDMA. Eyeballing can be horrendously inaccurate.

Know the dose for specific route of administration

Don’t confuse the intranasal dose with the oral dose, for example. Those can be very different things.

Start out small, increase the next time

Research is good but I’d generally say that its always good to start lower than you’d like and work your way up.

“Those who received a small taster before a higher dose were observed as being even more likely to reap the benefits than those who were only given the higher dose.”

About study participants from John Hopkins’ psilocybin study – Link

The great Czech psychedelic pioneer Stanislav Grof used a step up approach in his psycholytic psychedelic therapy work. After some sessions to build trust between the therapist and patient, he would start patients on 100 micrograms of LSD, and gradually work them up on consecutive sessions until an optimum dose was reached. 

Make use of boosters

You can use a booster. This means adding a second dose on top of the first to boost the effect. The key to getting the booster right is the timing. If you add too early, before the first dose has reached its peak, you risk taking too much. If you time it too late, you miss the chance of adding to the peak of the first dose and just extending the session – or having a second peak that is similar to the first. To counter this, take note of the time when you take your dose. Then consider setting an alarm as a reminder to check in with how you feel and to then make a decision on whether or not to take the booster.

With psilocybin taken on an empty stomach (no food for 2-3 hours before), the region of 60-80 minutes after the original dose is generally a good time to take a booster.

Use volumetric dosing for microdosing LSD

Volumetric dosing enables you to be very accurate and precise with dosage when you have paper tabs of LSD. You can find a guide on how to here.

Keep a drug journal

Logging and tracking have become quite a thing in the self-improvement field and for good reason. By tracking our behaviours we get good solid data that we can assess objectively. Using only a scale and a notebook, you can track and log your ingestions and doses and make notes on the effects, gaining precious personalised data. 

Maybe you’ve heard of a food diary to raise awareness of what you are eating. Or a smoke diary for people trying to quit. Logging and tracking raises awareness of our behaviours, feelings, triggers and patterns.

Keeping a drug diary has to have been one of the most useful things I’ve ever done in regards to learning about my relationship with different substances and what doses work for me. The data has been invaluable for deciding doses and finding my sweet spot for different applications and activities. I know my optimum kratom dose to enhance focus on a work day, my LSD minidose for a day out, and my MDMA dose for a session with friends, including booster and timing.

If you wanna know more about drug journaling, take a look at taking drugs like a nerd.

Don’t underestimate the dose. Better yet, overestimate it.

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How to Get the Dose Right with Psilocybin Truffles

One of the most important factors leading to a beneficial magic truffle session is finding a dosage that is well calibrated to your intention. I would argue that it is of equal importance to the set and setting when it comes to a positive outcome.

As magic truffles are kinda new in the psychedelic world compared to classic magic mushrooms, the doses are not well understood.

Below, I’ll share my calculations to match the doses of synthetic psilocybin used in 4 major and influential studies to the corresponding dose of magic truffles. Synthetic psilocybin is easy to measure and dose compared to raw mushrooms, and is therefore used exclusively in clinical trials. Below, I share my calculations.

psilocybin magic truffles

Doses Used In Clinical Research

1. Psilocybin-occasioned mystical-type experience

Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors – Roland R. Griffiths, Matthew W. Johnson, William A. Richards, Brian D. Richards, Robert Jesse, Katherine A. MacLean, Frederick S. Barrett, Mary P. Cosimano, and Maggie A. Klinedinst (2018)

Participants tripped twice, with a month between each session, with:
(1) high dose of 20 mg
(2) high dose of 30 mg
Doses calculated per 70kg bodyweight.

Study paper

2. Psilocybin with psychological support for treatment-resistant depression

Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study – Robin L. Carhart-Harris, Mark Bolstridge, James Rucker, Camilla M.J. Day, David Erritzoe, Mendel Kaelen, Michael Bloomfield, James A Rickard, Ben Forbes, Amanda Feilding, David Taylor, Steve Pilling, Valerie H. Curran, David J. Nutt (2016)

Participants tripped twice, with a week between each session:
(1) low dose of 10 mg
(2) high dose of 25 mg
Doses regardless of bodyweight.

Study paper

3. Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial – Roland R. Griffiths, Matthew W. Johnson, Michael A. Carducci, Annie Umbricht, William A. Richards, Brian D. Richards, Mary P. Cosimano and Margaret A. Klinedinst (2016)

Participants tripped twice, with 5 weeks between each session:
(1) high dose of 22 or 30 mg
(2) very low (placebo-like) dose of 1 or 3 mg
Doses calculated per 70kg bodyweight.

Study paper

4. Psilocybin in the Treatment of Tobacco Addiction

Pilot Study of the 5-HT2AR Agonist Psilocybin in the Treatment of Tobacco Addiction – Matthew W. Johnson, Albert Garcia-Romeu, Mary P. Cosimano, and Roland R. Griffiths (2014)

On a 15 week course participants tripped 2-3 times:
(1) moderate dose of 20mg at week 5
(2) moderate or high dose of 20 or 30 mg at week 7
(3) optional session with either 20 or 30 mg at week 13
Doses calculated per 70kg bodyweight.

Study paper

Converting to Fresh Truffle Weight

magic galindoi psilocybin truffles 15g packet

One 15 g pack of truffles

The exact psilocybin content of truffles is, as far as I can find, unknown, but going off of the calculation that 1 g of fresh truffles will contain between 0.75 and 1.75 mg of psilocybin (link), we have a reasonable window with which to find a comparable dosage of fresh truffles. Keep in mind that potency may vary by strain and that individual tolerance varies depending on both physiological and psychological factors (more on this another time).

The information below is presented as a rough guide and calculated with fresh truffle weight. (If your truffles are dried, the equivalent dose will be significantly less. Fully dried truffles are approximately ⅓ the weight of fresh truffles. So for example, if the fresh truffle dose was 13g, you could calculate 13 / 3 =  to get a dried truffle dose of 4.33 g.)

The best way to find the dosage right for you is through personal experience. Start low, document your sessions, and gradually work your way up.

If you are considering to go DIY and organise your own session at home or without a sitter, remember that the psilocybin sessions in the research studies mentioned are accompanied by psychological support before, during, and after each session.

Pure (Synthetic) Psilocybin Doses Converted to Truffle Weight

10 mg psilocybin – Low dose

10 / 0.75 = 13.33
10 / 1.25 = 8
10 / 1.75 = 5.71

6 – 13 g fresh truffles

–

20 mg psilocybin – Moderate dose

20 / 0.75 = 26.66
20 / 1.25 = 16
20 / 1.75 = 11.43

11 – 27 g fresh truffles

–

25 mg psilocybin – High dose

25 / 0.75 = 33.33
25 / 1.25 = 20
25 / 1.75 = 14.29

14 – 33 g fresh truffles

–

30 mg psilocybin – High dose

30 / 0.75 = 40
30 / 1.25 = 24
30 / 1.75 = 17.14

17 – 40 g fresh truffles

–

Final Thoughts

Generally speaking, I’d recommend lower doses for recreational trips, creative thinking, and active problem solving, and scaling up to higher doses for therapeutic experiences, deep inner journeys, and peak mystical experiences.

Safe journeys!

/by

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